Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285857 | 0.98 | ATM (0.62) | ATMALDH1A1SMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL18928680 | 0.84 | ATM (0.71) | ATMALDH1A1SMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL8133040 | 0.79 | — | — | |
| SCHEMBL2645083 | 0.77 | ATM (0.68) | ATMALDH1A1SMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL19574089 | 0.77 | ATM (0.95) | ATMALDH1A1SMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL5518648 | 0.77 | ATM (0.68) | ATMALDH1A1SMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL14041701 | 0.77 | ATM (0.68) | ATMALDH1A1SMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL4603153 | 0.77 | ATM (0.54) | ATMALDH1A1SMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL10722542 | 0.77 | ATM (0.85) | ATMALDH1A1SMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL27487132 | 0.77 | ATM (0.85) | ATMALDH1A1SMN1; SMN2L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021046437-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2021-03-11 | — | — | WO | disclosed |
| EP-3650484-A1 | KIDNEY-TARGETING DRUG DELIVERY CARRIER | Kyoto Pharmaceutical University (JP) | 2020-05-13 | — | — | EP | disclosed |
| US-9688628-B1 | Drug repositioning: urease inhibitory activity of (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid (captopril) | KHAN JALALUDDIN AZAM JALAL (SA) | 2017-06-27 | — | — | US | disclosed |
| EP-1694748-B1 | METHOD OF MODIFYING A FLUOROPOLYMERIC SUBSTRATE AND COMPOSITE ARTICLES THEREBY | 3M INNOVATIVE PROPERTIES CO (US) | 2008-04-23 | — | — | EP | disclosed |
| US-7273531-B2 | Method of modifying a fluoropolymeric substrate and composite articles thereby | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-09-25 | — | — | US | disclosed |
| EP-1694748-A1 | METHOD OF MODIFYING A FLUOROPOLYMERIC SUBSTRATE AND COMPOSITE ARTICLES THEREBY | 3M Innovative Properties Company (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005047373-A1 | METHOD OF MODIFYING A FLUOROPOLYMERIC SUBSTRATE AND COMPOSITE ARTICLES THEREBY | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2005-05-26 | — | — | WO | disclosed |
| US-20050092429-A1 | Method of modifying a fluoropolymeric substrate and composite articles thereby | 3M INNOVATIVE PROPERTIES COMPANY | 2005-05-05 | — | — | US | disclosed |