Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.55 |
| ▸ | TNF | P01375 | 4/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.53 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.53 |
| ▸ | HCK | P08631 | 5/20 | 0.53 |
| ▸ | SRC | P12931 | 4/20 | 0.53 |
| ▸ | BRAF | P15056 | 3/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | MUSK | O15146 | 1/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4601517 | 0.84 | MAPK14 (0.55) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL4601507 | 0.83 | MAPK14 (0.55) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL295776 | 0.80 | MAPK14 (0.70) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL29593878 | 0.80 | MAPK14 (0.70) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL4603759 | 0.79 | MAPK14 (0.57) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL4603194 | 0.78 | MAPK14 (0.60) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL4601509 | 0.78 | MAPK14 (0.64) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL6680086 | 0.77 | MAPK14 (0.72) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL1619962 | 0.76 | MAPK14 (0.59) | MAPK14TNFMAPK12MAPK13MAPK11 | |
| SCHEMBL3886613 | 0.75 | MAPK14 (0.53) | MAPK14MAPK12MAPK13MAPK11DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |