Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 4/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 12/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4604110 | 0.89 | MAPK14 (0.68) | MAPK13MAPK14MAPK12MAPK11MAPK9 | |
| SCHEMBL4602777 | 0.87 | MAPK14 (0.66) | MAPK13MAPK14MAPK12MAPK11MAPK9 | |
| SCHEMBL4605357 | 0.84 | MAPK14 (0.60) | MAPK13MAPK14MAPK12MAPK11MAPK9 | |
| SCHEMBL4603204 | 0.84 | MAPK14 (0.68) | MAPK13MAPK14MAPK12MAPK11MAPK9 | |
| SCHEMBL16859849 | 0.83 | MAPK13 (1.00) | MAPK13MAPK14MAPK12MAPK11MAPK9 | |
| SCHEMBL2951206 | 0.82 | MAPK14 (0.74) | MAPK13MAPK14MAPK12MAPK11MAPK9 | |
| SCHEMBL2953791 | 0.82 | MAPK14 (0.74) | MAPK13MAPK14MAPK12MAPK11MAPK9 | |
| SCHEMBL4602154 | 0.82 | MAPK14 (0.73) | MAPK13MAPK14MAPK12MAPK11MAPK9 | |
| SCHEMBL4602075 | 0.81 | MAPK14 (0.72) | MAPK13MAPK14MAPK12MAPK11MAPK9 | |
| SCHEMBL4604560 | 0.81 | MAPK14 (0.78) | MAPK13MAPK14MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |