Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | NQO2 | P16083 | 1/20 | 0.59 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.59 |
| ▸ | FECH | P22830 | 1/20 | 0.59 |
| ▸ | JAK1 | P23458 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.59 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.59 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.59 |
| ▸ | CLK1 | P49759 | 1/20 | 0.59 |
| ▸ | CLK2 | P49760 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4604747 | 0.94 | CLK2 (0.67) | GAKDYRK3JAK2PRKD3MAP4K4 | |
| SCHEMBL5373329 | 0.91 | CLK2 (0.68) | GAKDYRK3JAK2PRKD3MAP4K4 | |
| SCHEMBL5372572 | 0.82 | MAPK8 (0.62) | GAKDYRK3JAK2PRKD3MAP4K4 | |
| SCHEMBL5380287 | 0.82 | MAPK8 (0.71) | GAKDYRK3JAK2PRKD3MAP4K4 | |
| SCHEMBL5375708 | 0.76 | GAK (0.62) | GAKDYRK3JAK2PRKD3MAP4K4 | |
| SCHEMBL5373334 | 0.76 | CLK2 (0.98) | GAKDYRK3JAK2PRKD3MAP4K4 | |
| SCHEMBL5373389 | 0.76 | CHEK2 (0.56) | GAKDYRK3JAK2PRKD3MAP4K4 | |
| SCHEMBL5380905 | 0.75 | MAPK8 (0.71) | GAKDYRK3JAK2PRKD3MAP4K4 | |
| SCHEMBL7532858 | 0.75 | MAPK8 (0.71) | GAKDYRK3JAK2PRKD3MAP4K4 | |
| Cc-401 SCHEMBL30290855 | 0.75 | CLK2 (1.00) | GAKDYRK3JAK2PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871364-A1 | METHODS FOR TREATING OR PREVENTING ACUTE MYELOGENOUS LEUKEMIA | Signal Pharmaceuticals LLC (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006102363-A1 | METHODS FOR TREATING OR PREVENTING ACUTE MYELOGENOUS LEUKEMIA | SIGNAL PHARMACEUTICALS, LLC (US) | 2006-09-28 | — | — | WO | disclosed |