Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.34 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12457558 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2CYP2A6CYP11B2KMOCYP11B1 | |
| SCHEMBL12275578 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2CYP11B2HIF1ANPSR1RXFP1 | |
| SCHEMBL4607798 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2CYP11B2KMOCYP11B1ABCC9 | |
| SCHEMBL19756413 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2CYP11B2KMOCYP11B1ABCC9 | |
| SCHEMBL1092164 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2HIF1ANPSR1RXFP1ALDH1A1 | |
| SCHEMBL14991759 | 0.77 | CYP2A6 (0.41) | SMN1; SMN2CYP2A6PTK2CYP11B2PTGS2 | |
| SCHEMBL583651 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2HIF1ANPSR1RXFP1KMO | |
| SCHEMBL12523381 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2CYP11B2KMOALDH1A1CYP2C9 | |
| SCHEMBL12458872 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2CYP11B2KMOCYP11B1ABCC9 | |
| SCHEMBL420682 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2HIF1ANPSR1RXFP1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306067-A1 | Modulators of Chemokine Receptor Activity | WEIGAND KLAUS | 2008-12-11 | — | — | US | disclosed |
| EP-1943235-A1 | ARYLUREA DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Novartis AG (CH) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007048771-A1 | ARYLUREA DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | NOVARTIS AG (CH) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306067-A1 | Modulators of Chemokine Receptor Activity | CCR3, CCR1, CCR4 | SMN1; SMN2 4305/4885CYP2A6 1863/4885PTK2 1999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.