Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9475614 | 1.00 | MAPT (0.66) | MAPTNPSR1MAOBMEN1KMT2A | |
| SCHEMBL4608089 | 1.00 | MAPT (0.66) | MAPTNPSR1MAOBMEN1KMT2A | |
| SCHEMBL4608087 | 1.00 | MAPT (0.66) | MAPTNPSR1MAOBMEN1KMT2A | |
| SCHEMBL8038703 | 0.92 | MAPT (0.71) | MAPTNPSR1MAOBMEN1KMT2A | |
| SCHEMBL7829312 | 0.90 | MAPT (0.69) | MAPTNPSR1MAOBMEN1KMT2A | |
| SCHEMBL7829304 | 0.90 | MAPT (0.69) | MAPTNPSR1MAOBMEN1KMT2A | |
| Propylene Glycol SCHEMBL1639493 | 0.87 | MAPT (0.52) | MAPTNPSR1MAOBMEN1KMT2A | |
| SCHEMBL8464902 | 0.87 | MAPT (0.61) | MAPTNPSR1MAOBMEN1KMT2A | |
| SCHEMBL8464899 | 0.87 | MAPT (0.61) | MAPTNPSR1MAOBMEN1KMT2A | |
| SCHEMBL7250786 | 0.86 | MAPT (0.64) | MAPTNPSR1MAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532110-B1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) | ERREGIERRE SPA (IT) | 2008-07-23 | — | — | EP | claimed |
| EP-1532110-A1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) | ERREGIERRE S.p.A. (IT) | 2005-05-25 | — | — | EP | claimed |
| WO-2004002958-A1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) | ERREGIERRE, S.P.A. (IT) | 2004-01-08 | — | — | WO | claimed |
| EP-0220653-B1 | 3-AMINOCARBONYL-1,4-DIHYDROPYRIDINE-5-CARBOXYLIC ACID COMPOUNDS, PROCESS FOR PREPARATION AND USE THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Nippon Shoji Kabushiki Kaisha (JP) | 1991-11-06 | — | — | EP | disclosed |
| US-4874773-A | HYPOTENSIVE AGENTS, VASODILATORS | NIPPON SHOJI KABUSHIKI KAISHA (JP) | 1989-10-17 | — | — | US | disclosed |
| EP-0220653-A2 | 3-Aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid compounds, process for preparation and use thereof, and pharmaceutical composition containing the same | Nippon Shoji Kabushiki Kaisha (JP) | 1987-05-06 | — | — | EP | disclosed |