Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608555 | 1.00 | MAPT (0.60) | MAPTNPSR1GLO1GAAHPGD | |
| SCHEMBL29043783 | 0.86 | MAPT (0.64) | MAPTNPSR1GLO1GAAHPGD | |
| SCHEMBL10386660 | 0.86 | MAPT (0.64) | MAPTNPSR1GLO1GAAHPGD | |
| SCHEMBL7270940 | 0.86 | MAPT (0.64) | MAPTNPSR1GLO1GAAHPGD | |
| SCHEMBL30553800 | 0.86 | MAPT (0.64) | MAPTNPSR1GLO1GAAHPGD | |
| SCHEMBL7282260 | 0.84 | MAPT (0.64) | MAPTNPSR1GLO1GAAHPGD | |
| SCHEMBL10661942 | 0.84 | MAPT (0.64) | MAPTNPSR1GLO1GAAHPGD | |
| SCHEMBL10377587 | 0.83 | MAPT (0.64) | MAPTNPSR1GLO1ALDH1A1STAT3 | |
| SCHEMBL7374470 | 0.83 | MAPT (0.60) | MAPTNPSR1GLO1ALDH1A1KMT2A | |
| SCHEMBL7271101 | 0.83 | MAPT (0.64) | MAPTNPSR1GLO1ALDH1A1STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532110-B1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) | ERREGIERRE SPA (IT) | 2008-07-23 | — | — | EP | claimed |
| US-7060838-B2 | Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine) | ERREGIERRE, S.P.A. (IT) | 2006-06-13 | — | — | US | claimed |
| US-20050240022-A1 | Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine) | ERREGIERRE, S.P.A. (IT) | 2005-10-27 | — | — | US | claimed |
| EP-1532110-A1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) | ERREGIERRE S.p.A. (IT) | 2005-05-25 | — | — | EP | claimed |
| WO-2004002958-A1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) | ERREGIERRE, S.P.A. (IT) | 2004-01-08 | — | — | WO | claimed |
| EP-1532110-B1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) | ERREGIERRE SPA (IT) | 2008-07-23 | — | — | EP | disclosed |
| EP-1532110-B1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) | ERREGIERRE SPA (IT) | 2008-07-23 | — | — | EP | disclosed |
| US-7060838-B2 | Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine) | ERREGIERRE, S.P.A. (IT) | 2006-06-13 | — | — | US | disclosed |
| US-7060838-B2 | Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine) | ERREGIERRE, S.P.A. (IT) | 2006-06-13 | — | — | US | disclosed |
| US-20050240022-A1 | Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine) | ERREGIERRE, S.P.A. (IT) | 2005-10-27 | — | — | US | disclosed |
| US-20050240022-A1 | Industrial process for the synthesis of isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxylate (nisoldipine) | ERREGIERRE, S.P.A. (IT) | 2005-10-27 | — | — | US | disclosed |
| EP-1532110-A1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) | ERREGIERRE S.p.A. (IT) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002958-A1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) | ERREGIERRE, S.P.A. (IT) | 2004-01-08 | — | — | WO | disclosed |
| WO-2004002958-A1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF ISOBUTYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE (NISOLDIPINE) | ERREGIERRE, S.P.A. (IT) | 2004-01-08 | — | — | WO | disclosed |
| CN-1042727-C | Preparing for 2-acetoacetic ester | XINHUA PHARMACEUTIC FACTORY SH (CN) | 1999-03-31 | — | — | CN | disclosed |
| CN-1080631-A | 2-(oil of mirbane methylene radical) acetylacetic ester method for making | SHANDONG XINHUA PHARMACEUTIC F (CN) | 1994-01-12 | — | — | CN | disclosed |
| US-4798840-A | Coronary-active fluorine-containing 1,4-dihydropyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1989-01-17 | — | — | US | disclosed |
| US-4757080-A | Pharmaceuticals | HEUMANN PHARMA GMBH & CO. (DE) | 1988-07-12 | — | — | US | disclosed |
| US-4703119-A | Intermediates of optically active 1,4-dihydropyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1987-10-27 | — | — | US | disclosed |
| US-4154839-A | INCREASING CORONARY PERFUSION | BAYER AKTIENGESELLSCHAFT (DE) | 1979-05-15 | — | — | US | disclosed |