Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 4/20 | 0.36 |
| ▸ | APAF1 | O14727 | 3/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 3/20 | 0.36 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GALK1 | P51570 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL8926769 | 0.94 | DNMT1 (0.42) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL9678206 | 0.93 | DNMT1 (0.39) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL16419 | 0.92 | MAPT (0.42) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL11422311 | 0.92 | MAPT (0.42) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL4334317 | 0.91 | DNMT1 (0.40) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL738610 | 0.90 | DNMT1 (0.42) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL3101456 | 0.90 | DNMT1 (0.47) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL6000230 | 0.90 | DNMT1 (0.47) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL5054475 | 0.90 | DNMT1 (0.47) | DNMT1MAPTHTTTP53STAT3 | |
| Triaziquone SCHEMBL7088197 | 0.90 | DNMT1 (0.47) | DNMT1MAPTHTTTP53STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070031910-A1 | Method of stabilizing sample | ARKRAY, INC. (JP) | 2007-02-08 | — | — | US | claimed |
| EP-1628134-A1 | METHOD OF STABILIZING SAMPLE | ARKRAY, Inc. (JP) | 2006-02-22 | — | — | EP | claimed |
| WO-2024036507-A1 | ELECTROCHEMICAL DEVICE AND ELECTRONIC DEVICE | 宁德新能源科技有限公司 | 2024-02-22 | — | — | WO | disclosed |
| CN-112300435-A | Environment-friendly polyurethane foaming agent and preparation method thereof | 宋庆红 | 2021-02-02 | — | — | CN | disclosed |
| EP-1443327-B1 | Biochemical and immunochemical assay device | DIAMATRIX LTD (GB) | 2008-07-30 | — | — | EP | disclosed |
| US-7303923-B2 | Biochemical and immunochemical assay device | DIAMATRIX LIMITED (GB) | 2007-12-04 | — | — | US | disclosed |
| US-20070031910-A1 | Method of stabilizing sample | ARKRAY, INC. (JP) | 2007-02-08 | — | — | US | disclosed |
| CN-1795381-A | Method for stabilizing hemolyzed sample | ARKRAY INC (JP) | 2006-06-28 | — | — | CN | disclosed |
| EP-1628134-A1 | METHOD OF STABILIZING SAMPLE | ARKRAY, Inc. (JP) | 2006-02-22 | — | — | EP | disclosed |
| EP-1443327-A2 | Biochemical and immunochemical assay device | DIAMATRIX LIMITED (GB) | 2004-08-04 | — | — | EP | disclosed |
| EP-0968426-B1 | BIOCHEMICAL AND IMMUNOCHEMICAL ASSAY DEVICE | DIAMATRIX LTD (GB) | 2004-04-07 | — | — | EP | disclosed |
| US-4794077-A | DIAGNOSIS | BIOSCIENCES CORPORATION OF TEXAS (US) | 1988-12-27 | — | — | US | disclosed |
| EP-0284429-A2 | Antibodies to human cancer nucleolar antigen pl20, corresponding cell lines, and their preparation and use in the detection of human cancer cells | BIOSCIENCES CORPORATION OF TEXAS (US) | 1988-09-28 | — | — | EP | disclosed |
| EP-0259949-A2 | Method of improving optical clarity in reconstituted lyophilized products | TECHNICON INSTRUMENTS CORPORATION(a Delaware corporation) (US) | 1988-03-16 | — | — | EP | disclosed |
| EP-0226468-A2 | Detection of human cancer cells with antibodies to human cancer nucleolar antigen p145 | ONCOS, LTD. (US) | 1987-06-24 | — | — | EP | disclosed |
| EP-0016573-B1 | ENZYME REFERENCE COMPOSITION | BECKMAN INSTRUMENTS, INC. (US) | 1984-06-13 | — | — | EP | disclosed |
| US-4448890-A | DIAGNOSTIC KITS | BAYLOR COLLEGE OF MEDICINE (US) | 1984-05-15 | — | — | US | disclosed |
| US-4325832-A | POLYOXYALKYLENE GLYCOL, PROTEIN | BECKMAN INSTRUMENTS, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| EP-0016573-A1 | Enzyme reference composition | BECKMAN INSTRUMENTS, INC. (US) | 1980-10-01 | — | — | EP | disclosed |
| US-4089747-A | OXIDATION OF DYE-PROVIDING MATERIALS, A SULFONYL HYDRAZONE AND A COUPLER OR A TRIARYLIMIDAZOLE | EASTMAN KODAK COMPANY (US) | 1978-05-16 | — | — | US | disclosed |