Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | HTR2C | P28335 | 6/20 | 0.44 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.36 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 3/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2450377 | 0.87 | MAPK14 (0.55) | MAPK14HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL2446126 | 0.83 | MAPK14 (0.56) | MAPK14HTR2AHTR2CHTR2BKMO | |
| SCHEMBL4610566 | 0.82 | MAPK14 (0.62) | MAPK14HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL4609146 | 0.81 | MAPK14 (0.57) | MAPK14HTR2AHTR2CHIPK4SCN9A | |
| SCHEMBL4610157 | 0.81 | MAPK14 (0.46) | MAPK14SCN9AMCHR2MCHR1 | |
| SCHEMBL4608602 | 0.80 | MAPK14 (0.48) | MAPK14HTR2AHTR2CHTR1AHTR7 | |
| SCHEMBL4611378 | 0.79 | MAPK14 (0.45) | MAPK14MCHR2MCHR1NR3C1 | |
| SCHEMBL14312174 | 0.79 | MAPK14 (0.63) | MAPK14HTR2AHTR2CKMOCARM1 | |
| SCHEMBL2474183 | 0.78 | MAPK14 (0.61) | MAPK14HTR2AHTR2CHTR2BKMO | |
| SCHEMBL4611567 | 0.77 | MAPK14 (0.44) | MAPK14SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606283-B1 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2008-10-08 | — | — | EP | claimed |