Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 6/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4606451 | 0.83 | PDE4B (0.71) | PDE4BCSF1RLRRK2 | |
| SCHEMBL27777073 | 0.80 | CSF1R (0.70) | CSF1RLRRK2SCN5AEGFRKCNH2 | |
| SCHEMBL4608167 | 0.76 | LRRK2 (0.41) | PDE4BCSF1RLRRK2 | |
| SCHEMBL4930884 | 0.76 | PDE4B (0.51) | PDE4BCSF1RLRRK2EGFR | |
| SCHEMBL4606247 | 0.75 | LRRK2 (0.44) | LRRK2 | |
| SCHEMBL4930902 | 0.73 | LRRK2 (0.39) | CSF1RLRRK2 | |
| SCHEMBL4609629 | 0.73 | PDE4B (0.58) | PDE4BCSF1RLRRK2EGFR | |
| SCHEMBL27777167 | 0.71 | CSF1R (0.63) | CSF1REGFR | |
| SCHEMBL1276789 | 0.70 | SCN5A (0.74) | CSF1RSCN5AEGFRKCNH2 | |
| SCHEMBL27777074 | 0.69 | SCN5A (0.60) | CSF1RSCN5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280911-A1 | Cinnoline Compounds as Inhibitors of Phosphodiesterase Type IV (Pde4) | GLAXO GROUP LIMITED (GB) | 2008-11-13 | — | — | US | disclosed |
| EP-1945616-A1 | CINNOLINE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE TYPE IV (PDE4) | GLAXO GROUP LIMITED (GB) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007045861-A1 | CINNOLINE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE TYPE IV (PDE4) | GLAXO GROUP LIMITED (GB) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280911-A1 | Cinnoline Compounds as Inhibitors of Phosphodiesterase Type IV (Pde4) | PDE4A, PDE4B, PDE3B | PDE4B 2/4885CSF1R 3778/4885LRRK2 2855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.