Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.84 |
| ▸ | PDE4A | P27815 | 1/20 | 0.82 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.82 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.82 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.82 |
| ▸ | APP | P05067 | 1/20 | 0.80 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.72 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | XDH | P47989 | 1/20 | 0.65 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30138930 | 1.00 | MAPT (0.84) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2462050 | 0.91 | MAPT (1.00) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2462049 | 0.91 | MAPT (1.00) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4446313 | 0.89 | APP (1.00) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4446319 | 0.89 | APP (1.00) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19183199 | 0.86 | APP (0.81) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19183197 | 0.86 | APP (0.81) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4618386 | 0.85 | MAPT (0.87) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28681178 | 0.85 | MAPT (0.95) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16625566 | 0.85 | MAPT (0.87) | MAPTPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976818-A2 | CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD - LYON 1 (FR) | 2008-10-08 | — | — | EP | claimed |
| WO-2007083060-A2 | NOVEL CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD LYON I (FR) | 2007-07-26 | — | — | WO | claimed |
| EP-1976818-A2 | CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD - LYON 1 (FR) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007083060-A2 | NOVEL CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY | UNIVERSITE CLAUDE BERNARD LYON I (FR) | 2007-07-26 | — | — | WO | disclosed |