Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 2/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.31 |
| ▸ | LDHB | P07195 | 1/20 | 0.31 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.31 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.31 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8042496 | 1.00 | CA1 (0.62) | CA1CA2CA9TSHRACHE | |
| Bicarbonate SCHEMBL1925200 | 0.94 | — | — | |
| Bicarbonate SCHEMBL28317678 | 0.94 | — | — | |
| Bicarbonate SCHEMBL8372743 | 0.94 | CA1 (0.71) | CA1CA2CA9TSHRACHE | |
| Bicarbonate SCHEMBL13725824 | 0.94 | CA1 (0.71) | CA1CA2CA9TSHRACHE | |
| Bicarbonate SCHEMBL81420 | 0.94 | — | — | |
| Bicarbonate SCHEMBL81418 | 0.88 | — | — | |
| Bicarbonate SCHEMBL5066729 | 0.88 | CA1 (0.62) | CA1CA2CA9TSHRACHE | |
| Bicarbonate SCHEMBL8017866 | 0.88 | CA1 (0.62) | CA1CA2CA9TSHRACHE | |
| Bicarbonate SCHEMBL669861 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1978935-B1 | COATED FORMULATIONS | LEK PHARMACEUTICALS (SI) | 2015-01-07 | — | — | EP | disclosed |
| EP-1978935-A1 | COATED FORMULATIONS | LEK Pharmaceuticals D.D. (SI) | 2008-10-15 | — | — | EP | disclosed |
| US-7341742-B2 | Simethicone containing tablet composition and method | L. PERRIGO COMPANY (US) | 2008-03-11 | — | — | US | disclosed |
| WO-2007082770-A1 | COATED FORMULATIONS | LEK PHARMACEUTICALS D.D. (SI) | 2007-07-26 | — | — | WO | disclosed |
| EP-1810668-A1 | Coated formulations containing tolterodine tartrate | LEK Pharmaceuticals D.D. (SI) | 2007-07-25 | — | — | EP | disclosed |
| US-20040063664-A1 | Simethicone containing tablet composition and method | L. PERRIGO COMPANY | 2004-04-01 | — | — | US | disclosed |
| US-5382384-A | Thermoplastic and thermosetting blends for heat resistance | RAYCHEM CORPORATION (US) | 1995-01-17 | — | — | US | disclosed |
| EP-0553194-A4 | EFFECTIVE SOLID NON-LOZENGE ANTI-ACID/ANTI-GAS MEDICAMENT | — | 1993-09-08 | — | — | EP | disclosed |
| EP-0553194-A1 | EFFECTIVE SOLID NON-LOZENGE ANTI-ACID/ANTI-GAS MEDICAMENT | Beecham Inc. (US) | 1993-08-04 | — | — | EP | disclosed |
| WO-1992004889-A1 | EFFECTIVE SOLID NON-LOZENGE ANTI-ACID/ANTI-GAS MEDICAMENT | BEECHAM INCORPORATED (US) | 1992-04-02 | — | — | WO | disclosed |
| US-4396604-A | COOKING, HEAT EXCHANGING | NORCLIFF THAYER, INC. (US) | 1983-08-02 | — | — | US | disclosed |