Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12726995 | 0.90 | HRH3 (0.51) | HRH3CYP1A2CYP2D6L3MBTL1LTA4H | |
| SCHEMBL31436872 | 0.87 | HRH3 (0.51) | HRH3CYP1A2CYP2D6TDP1SIGMAR1 | |
| SCHEMBL21813123 | 0.85 | TSHR (0.50) | HRH3CYP1A2CYP2D6SIGMAR1 | |
| SCHEMBL1881035 | 0.82 | HRH3 (0.53) | HRH3CYP1A2CYP2D6LTA4HTDP1 | |
| SCHEMBL17863636 | 0.82 | HRH3 (0.43) | HRH3CYP1A2CYP2D6ATMEPHX2 | |
| SCHEMBL1873045 | 0.81 | HRH3 (0.55) | HRH3CYP1A2CYP2D6L3MBTL1LTA4H | |
| SCHEMBL2327396 | 0.80 | DPP7 (0.49) | HRH3CYP1A2CYP2D6L3MBTL1LTA4H | |
| SCHEMBL82422 | 0.79 | HRH3 (0.67) | HRH3CYP1A2CYP2D6L3MBTL1EPHX2 | |
| SCHEMBL19313504 | 0.79 | HRH3 (0.62) | HRH3CYP1A2CYP2D6L3MBTL1LTA4H | |
| SCHEMBL25353895 | 0.79 | ATM (0.51) | HRH3CYP1A2CYP2D6L3MBTL1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948605-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |