SCHEMBL4610862

SCHEMBL4610862

NC(C=Cc1ccccc1)(Cc1ccccc1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.56
SMN1; SMN2 Q16637 2/20 0.53
HIF1A Q16665 1/20 0.53
LMNA P02545 2/20 0.41
MMP1 P03956 2/20 0.41
MMP2 P08253 2/20 0.41
MMP9 P14780 2/20 0.41
PAM P19021 1/20 0.41
ALDH1A1 P00352 2/20 0.40
CYP2C9 P11712 2/20 0.40
RECQL P46063 2/20 0.40
ARG1 P05089 1/20 0.40
ARG2 P78540 1/20 0.40
HDAC3 O15379 1/20 0.40
TNKS O95271 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HCAR2 Q8TDS4 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17633993 0.81 SMN1; SMN2 (0.58) CYP2C19SMN1; SMN2HIF1AALDH1A1CYP2C9
SCHEMBL8381518 0.81 SMN1; SMN2 (0.58) CYP2C19SMN1; SMN2HIF1AALDH1A1CYP2C9
SCHEMBL6717503 0.81 SMN1; SMN2 (0.58) CYP2C19SMN1; SMN2HIF1AALDH1A1CYP2C9
SCHEMBL8385923 0.79 SMN1; SMN2 (0.60) CYP2C19SMN1; SMN2HIF1ALMNAALDH1A1
SCHEMBL8385924 0.79 SMN1; SMN2 (0.60) CYP2C19SMN1; SMN2HIF1ALMNAALDH1A1
SCHEMBL12735199 0.74 SMN1; SMN2 (0.50) CYP2C19SMN1; SMN2HIF1ALMNAMMP1
SCHEMBL12583597 0.74 SMN1; SMN2 (0.50) CYP2C19SMN1; SMN2HIF1ALMNAMMP1
SCHEMBL10802339 0.73 SMN1; SMN2 (0.53) CYP2C19SMN1; SMN2HIF1AALDH1A1CYP2C9
SCHEMBL28168376 0.73 SMN1; SMN2 (0.53) CYP2C19SMN1; SMN2HIF1AALDH1A1CYP2C9
SCHEMBL27590996 0.71 CYP2C19 (0.49) CYP2C19SMN1; SMN2LMNAPAMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923544-B1 METHOD FOR THE SYNTHESIS OF AMINES AND AMINO ACIDS WITH ORGANOBORON DERIVATIVES UNIV SOUTHERN CALIFORNIA (US) 2008-10-15 EP disclosed
US-6232467-B1 BIOSYNTHESIS OF AN AMINE WITH KETONE AND BORON COMPOUND; COMPOUNDLIBRARIES UNIVERSITY OF SOUTHERN CALIFORNIA 2001-05-15 US disclosed
EP-0923544-A4 METHOD FOR THE SYNTHESIS OF AMINES AND AMINO ACIDS WITH ORGANOBORON DERIVATIVES UNIV SOUTHERN CALIFORNIA (US) 1999-11-03 EP disclosed
EP-0923544-A1 METHOD FOR THE SYNTHESIS OF AMINES AND AMINO ACIDS WITH ORGANOBORON DERIVATIVES University of Southern California (US) 1999-06-23 EP disclosed
WO-1998000398-A1 METHOD FOR THE SYNTHESIS OF AMINES AND AMINO ACIDS WITH ORGANOBORON DERIVATIVES UNIVERSITY OF SOUTHERN CALIFORNIA (US) 1998-01-08 WO disclosed