Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.64 |
| ▸ | PPARD | Q03181 | 2/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | LIFR | P42702 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | FABP1 | P07148 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6189455 | 0.88 | NR1H4 (0.66) | NR1H4PPARDNR1I2CYP1A2CYP3A4 | |
| SCHEMBL4426173 | 0.83 | NR1H4 (0.78) | NR1H4LIFRMEN1FABP1THRB | |
| SCHEMBL21624448 | 0.81 | NR1H4 (0.69) | NR1H4PPARDNR1I2CYP1A2CYP3A4 | |
| SCHEMBL4838231 | 0.81 | NR1H4 (0.85) | NR1H4PPARDLIFRMEN1FABP1 | |
| SCHEMBL4598944 | 0.80 | NR1H4 (0.87) | NR1H4PPARDLIFRMEN1FABP1 | |
| SCHEMBL4426866 | 0.79 | NR1H4 (0.86) | NR1H4PPARDLIFRMEN1FABP1 | |
| SCHEMBL3806432 | 0.79 | NR1H4 (0.73) | NR1H4NR1I2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL21244210 | 0.79 | NR1H4 (0.72) | NR1H4PPARDLIFR | |
| SCHEMBL14279685 | 0.79 | NR1H4 (0.82) | NR1H4PPARDLIFR | |
| SCHEMBL4611112 | 0.78 | NR1H4 (0.79) | NR1H4PPARDLIFRMEN1FABP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008039829-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-04-03 | — | — | WO | disclosed |
| EP-1885694-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2008-02-13 | — | — | EP | disclosed |
| EP-1877067-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONE GLUCURONIDE DERIVATIVES FOR HYPERCHOLESTEROLEMIA | Microbia, Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| EP-1877373-A2 | BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS | Microbia, Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006124713-A2 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-23 | — | — | WO | disclosed |
| WO-2006121861-A2 | BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS | MICROBIA, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
| WO-2006116499-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONE GLUCURONIDE DERIVATIVES FOR HYPERCHOLESTEROLEMIA | MICROBIA, INC. (US) | 2006-11-02 | — | — | WO | disclosed |