Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | MGAM | O43451 | 9/20 | 0.42 |
| ▸ | GAA | P10253 | 9/20 | 0.42 |
| ▸ | SI | P14410 | 9/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 9/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27722998 | 0.89 | HDAC3 (0.58) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| Hydroxyamine SCHEMBL1326622 | 0.89 | HDAC3 (0.57) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1305750 | 0.86 | HDAC1 (0.76) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1305474 | 0.75 | HDAC3 (0.65) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1306240 | 0.75 | HDAC3 (0.65) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1305729 | 0.75 | HDAC3 (0.76) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1308378 | 0.75 | HDAC3 (0.76) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1306606 | 0.74 | HDAC3 (0.63) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1307627 | 0.73 | HDAC3 (0.74) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1308462 | 0.72 | HDAC3 (0.64) | HDAC3HDAC1HDAC2HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891007-A1 | INDOLE DERIVATIVES HAVING ANTITUMOR ACTIVITY | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-02-27 | — | — | EP | claimed |
| WO-2006131484-A1 | INDOLE DERIVATIVES HAVING ANTITUMOR ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-12-14 | — | — | WO | claimed |
| EP-1891007-A1 | INDOLE DERIVATIVES HAVING ANTITUMOR ACTIVITY | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006131484-A1 | INDOLE DERIVATIVES HAVING ANTITUMOR ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-12-14 | — | — | WO | disclosed |