Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Selegiline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 11/20 | 0.90 |
| ▸ | MAOA | P21397 | 8/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.90 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.90 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.90 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.90 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.90 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.90 |
| ▸ | SNCA | P37840 | 1/20 | 0.90 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.90 |
| ▸ | PKM | P14618 | 1/20 | 0.90 |
| ▸ | TSHR | P16473 | 1/20 | 0.90 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.88 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.88 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Selegiline SCHEMBL12248117 | 0.95 | MAOB (1.00) | MAOBMAOACYP1A2ADRA2BADRA2C | |
| Selegiline SCHEMBL15867136 | 0.95 | MAOB (1.00) | MAOBMAOACYP1A2ADRA2BADRA2C | |
| Selegiline SCHEMBL22232 | 0.95 | MAOB (1.00) | MAOBMAOACYP1A2ADRA2BADRA2C | |
| Selegiline SCHEMBL1286950 | 0.95 | MAOB (1.00) | MAOBMAOACYP1A2ADRA2BADRA2C | |
| Selegiline SCHEMBL5499736 | 0.95 | MAOB (1.00) | MAOBMAOACYP1A2ADRA2BADRA2C | |
| Selegiline SCHEMBL74753 | 0.95 | MAOB (1.00) | MAOBMAOACYP1A2ADRA2BADRA2C | |
| Selegiline SCHEMBL41392 | 0.93 | MAOB (1.00) | MAOBMAOACYP1A2ADRA2BADRA2C | |
| Selegiline SCHEMBL473659 | 0.93 | MAOB (1.00) | MAOBMAOACYP1A2ADRA2BADRA2C | |
| Selegiline SCHEMBL7105217 | 0.92 | MAOB (0.93) | MAOBMAOACYP1A2ADRA2BADRA2C | |
| Selegiline SCHEMBL1171497 | 0.92 | MAOB (0.93) | MAOBMAOACYP1A2ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204869-B1 | METHOD FOR ANALYZING A NUMBER OF SAMPLES FROM A VARIETY OF SOURCES FOR A SINGLE ANALYTE | LUMINEX CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| US-7141431-B2 | Microparticles with multiple fluorescent signals and methods of using same | LUMINEX CORPORATION (US) | 2006-11-28 | — | — | US | disclosed |
| US-20050277197-A1 | Microparticles with multiple fluorescent signals and methods of using same | LUMINEX CORPORATION | 2005-12-15 | — | — | US | disclosed |
| US-6916661-B2 | Microparticles with multiple fluorescent signals and methods of using same | LUMINEX CORPORATION (US) | 2005-07-12 | — | — | US | disclosed |
| US-20040087032-A1 | Microparticles with multiple fluorescent signals and methods of using same | CHANDLER MARK B (US) | 2004-05-06 | — | — | US | disclosed |
| US-6649414-B1 | Microparticles with multiple fluorescent signals and methods of using same | LUMINEX CORPORATION | 2003-11-18 | — | — | US | disclosed |
| EP-1049807-B1 | MICROPARTICLES WITH MULTIPLE FLUORESCENT SIGNALS | LUMINEX CORP (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-1204869-A1 | MICROPARTICLES WITH MULTIPLE FLUORESCENT SIGNALS AND METHODS OF USING SAME | Luminex Corporation (US) | 2002-05-15 | — | — | EP | disclosed |
| EP-1049807-A4 | MICROPARTICLES WITH MULTIPLE FLUORESCENT SIGNALS | LUMINEX CORP (US) | 2001-08-29 | — | — | EP | disclosed |
| US-6268222-B1 | Microparticles attached to nanoparticles labeled with flourescent dye | LUMINEX CORPORATION | 2001-07-31 | — | — | US | disclosed |
| WO-2001013120-A1 | MICROPARTICLES WITH MULTIPLE FLUORESCENT SIGNALS AND METHODS OF USING SAME | LUMINEX CORPORATION (US) | 2001-02-22 | — | — | WO | disclosed |
| EP-1049807-A1 | MICROPARTICLES WITH MULTIPLE FLUORESCENT SIGNALS | Luminex Corporation (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999037814-A9 | MICROPARTICLES WITH MULTIPLE FLUORESCENT SIGNALS | LUMINEX CORP (US) | 1999-10-14 | — | — | WO | disclosed |
| WO-1999037814-A1 | MICROPARTICLES WITH MULTIPLE FLUORESCENT SIGNALS | LUMINEX CORPORATION (US) | 1999-07-29 | — | — | WO | disclosed |