SCHEMBL4611959

SCHEMBL4611959

CC(C)(C)c1ccc2c(c1)CCC2NC(=O)Nc1cccc2c1cnn2C(=O)O

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 20/20 0.67
TRPV4 Q9HBA0 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4614100 1.00 TRPV1 (0.67) TRPV1TRPV4
SCHEMBL4613811 1.00 TRPV1 (0.67) TRPV1TRPV4
SCHEMBL1856985 0.93 TRPV1 (0.67) TRPV1TRPV4
SCHEMBL1857213 0.92 TRPV1 (0.66) TRPV1TRPV4
SCHEMBL1858836 0.92 TRPV1 (0.66) TRPV1TRPV4
SCHEMBL1855082 0.92 TRPV1 (0.66) TRPV1TRPV4
SCHEMBL4613478 0.91 TRPV1 (0.66) TRPV1TRPV4
SCHEMBL5469918 0.91 TRPV1 (0.64) TRPV1TRPV4
SCHEMBL5460588 0.90 TRPV1 (0.61) TRPV1TRPV4
SCHEMBL4611485 0.89 TRPV1 (0.71) TRPV1TRPV4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1658269-B1 FUSED COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR ABBOTT LAB (US) 2008-10-22 EP claimed