Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.76 |
| ▸ | BACE2 | Q9Y5Z0 | 14/20 | 0.76 |
| ▸ | APP | P05067 | 3/20 | 0.76 |
| ▸ | CTSD | P07339 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8189524 | 0.86 | BACE1 (1.00) | BACE1BACE2APPCTSD | |
| SCHEMBL8231970 | 0.85 | BACE1 (0.97) | BACE1BACE2APPCTSD | |
| SCHEMBL4599277 | 0.79 | BACE1 (0.72) | BACE1BACE2APPCTSD | |
| SCHEMBL4599272 | 0.79 | BACE1 (0.72) | BACE1BACE2APPCTSD | |
| Trifluoroacetic Acid SCHEMBL4229079 | 0.77 | BACE1 (0.80) | BACE1BACE2APPCTSD | |
| SCHEMBL4611233 | 0.76 | BACE1 (0.71) | BACE1BACE2APPCTSD | |
| SCHEMBL5146663 | 0.74 | BACE1 (0.77) | BACE1BACE2APPCTSD | |
| SCHEMBL5522143 | 0.74 | BACE1 (0.73) | BACE1BACE2APPCTSD | |
| SCHEMBL8414534 | 0.73 | BACE1 (0.63) | BACE1BACE2APPCTSD | |
| SCHEMBL4708358 | 0.73 | BACE1 (0.74) | BACE1BACE2APPCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910309-A2 | CYCLOALKYL AMINO-HYDANTOIN COMPOUNDS AND USE THEREOF FOR ß-SECRETASE MODULATION | Wyeth (US) | 2008-04-16 | — | — | EP | claimed |
| WO-2007016012-A2 | CYCLOALKYL AMINO-HYDANTOIN COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-02-08 | — | — | WO | claimed |