Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29832249 | 1.00 | PARP1 (0.50) | PARP1CSNK1A1TYRO3DYRK1BDAPK3 | |
| SCHEMBL29467366 | 1.00 | PARP1 (0.50) | PARP1CSNK1A1TYRO3DYRK1BDAPK3 | |
| SCHEMBL18066324 | 0.94 | PARP1 (0.48) | PARP1CSNK1A1TYRO3DYRK1BDAPK3 | |
| SCHEMBL16619215 | 0.83 | PARP1 (0.46) | PARP1CSNK1A1TYRO3DYRK1BDAPK3 | |
| SCHEMBL18066310 | 0.81 | PIM1 (0.47) | PARP1CSNK1A1DYRK1BDAPK3PRKD3 | |
| SCHEMBL18066326 | 0.80 | GSK3B (0.41) | PARP1CSNK1A1TYRO3DYRK1BDAPK3 | |
| SCHEMBL18066303 | 0.79 | PRKCI (0.47) | PARP1PRKD3MAP4K4PAK4ABL1 | |
| SCHEMBL29665034 | 0.77 | JAK2 (0.78) | CSNK1A1TYRO3DYRK1BDAPK3JAK2 | |
| SCHEMBL16619167 | 0.77 | RPS6KB1 (0.38) | PARP1CSNK1A1TYRO3DYRK1BDAPK3 | |
| SCHEMBL16619412 | 0.77 | RPS6KB1 (0.43) | PARP1RPS6KB1AURKAPDPK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907362-A1 | AMIDE DERIVATIVES AS KINASE INHIBITORS | Devgen NV (BE) | 2008-04-09 | — | — | EP | claimed |
| WO-2007006547-A1 | AMIDE DERIVATIVES AS KINASE INHIBITORS | DEVGEN N.V. (BE) | 2007-01-18 | — | — | WO | claimed |
| CN-109451740-B | Cyclic dinucleotides for the treatment of disorders associated with STING activity, such as cancer | 先天肿瘤免疫公司 | 2022-09-02 | — | — | CN | disclosed |
| EP-3894394-A1 | CYCLOBUTYL NUCLEOSIDE ANALOGS AS ANTI-VIRALS | Janssen BioPharma, Inc. (US) | 2021-10-20 | — | — | EP | disclosed |
| EP-3781687-A1 | NOVEL SUBSTITUTED RIG-I AGONISTS: COMPOSITIONS AND METHODS THEREOF | Merck Sharp&Dohme Corp. (US) | 2021-02-24 | — | — | EP | disclosed |
| WO-2020121122-A1 | CYCLOBUTYL NUCLEOSIDE ANALOGS AS ANTI-VIRALS | Janssen Biopharma, Inc. (US) | 2020-06-18 | — | — | WO | disclosed |
| WO-2019204179-A1 | NOVEL SUBSTITUTED RIG-I AGONISTS: COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2019-10-24 | — | — | WO | disclosed |