Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 19/20 | 0.38 |
| ▸ | IDH2 | P48735 | 7/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534113 | 0.83 | — | — | |
| SCHEMBL29883407 | 0.75 | ADORA2A (0.38) | POLB | |
| SCHEMBL4613663 | 0.75 | ADORA2A (0.38) | POLB | |
| SCHEMBL4613841 | 0.75 | POLB (0.59) | IDH2POLB | |
| SCHEMBL4612918 | 0.75 | POLB (0.39) | POLB | |
| SCHEMBL29884529 | 0.75 | MAPK1 (0.42) | POLB | |
| SCHEMBL21356705 | 0.72 | HRH3 (0.36) | POLB | |
| SCHEMBL23609130 | 0.71 | IDH1 (0.43) | IDH1IDH2POLB | |
| SCHEMBL12082316 | 0.71 | IDH1 (0.44) | IDH1IDH2POLB | |
| SCHEMBL698932 | 0.71 | IDH1 (0.39) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910358-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | Astellas Pharma Inc. (JP) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007007919-A2 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-01-18 | — | — | WO | disclosed |