Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 11/20 | 0.80 |
| ▸ | CDK2 | P24941 | 11/20 | 0.80 |
| ▸ | EIF2AK2 | P19525 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601088 | 0.89 | CDK4 (0.87) | CDK4CDK2EIF2AK2 | |
| SCHEMBL4615719 | 0.89 | CDK4 (1.00) | CDK4CDK2EIF2AK2 | |
| SCHEMBL4613384 | 0.89 | CDK2 (1.00) | CDK4CDK2EIF2AK2 | |
| SCHEMBL4615724 | 0.87 | CDK4 (0.78) | CDK4CDK2EIF2AK2 | |
| SCHEMBL4615032 | 0.87 | CDK2 (0.77) | CDK4CDK2EIF2AK2 | |
| SCHEMBL4613411 | 0.86 | CDK2 (0.78) | CDK4CDK2EIF2AK2 | |
| SCHEMBL4615351 | 0.85 | CDK4 (1.00) | CDK4CDK2EIF2AK2 | |
| SCHEMBL6603197 | 0.84 | CDK2 (0.76) | CDK4CDK2EIF2AK2 | |
| SCHEMBL4613588 | 0.83 | CDK4 (0.78) | CDK4CDK2EIF2AK2 | |
| SCHEMBL4613710 | 0.83 | CDK4 (1.00) | CDK4CDK2EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100519553-C | Inhiitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LTD (GB) | 2009-07-29 | — | — | CN | claimed |
| CN-100425239-C | Therapeutic applications of 2-substituted 4-heteroarylpyrimidines | CYCLACEL LTD (GB) | 2008-10-15 | — | — | CN | claimed |
| EP-1572211-B1 | THERAPEUTIC APPLICATIONS OF 2-SUBSTITUTED 4-HETEROARYLPYRIMIDINES | CYCLACEL LTD (GB) | 2008-02-20 | — | — | EP | claimed |
| US-7262202-B2 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LIMITED (GB) | 2007-08-28 | — | — | US | claimed |
| US-20070185134-A1 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LIMITED (GB) | 2007-08-09 | — | — | US | claimed |
| EP-1373253-B1 | INHIBITORS OF CYCLIN DEPENDENT KINASES AS ANTI-CANCER AGENT | CYCLACEL LTD (GB) | 2007-06-20 | — | — | EP | claimed |
| CN-1720049-A | Therapeutic applications of 2-substituted 4-heteroarylpyrimidines | CYCLACEL LTD (GB) | 2006-01-11 | — | — | CN | claimed |
| US-20050282843-A1 | Therapeutic applications of 2-substituted 4-heteroarylpyrimidines | CYCLACEL LIMITED (GB) | 2005-12-22 | — | — | US | claimed |
| EP-1572211-A1 | THERAPEUTIC APPLICATIONS OF 2-SUBSTITUTED 4-HETEROARYLPYRIMIDINES | Cyclacel Limited (GB) | 2005-09-14 | — | — | EP | claimed |
| US-20040132746-A1 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LIMITED (GB) | 2004-07-08 | — | — | US | claimed |
| WO-2004056368-A1 | THERAPEUTIC APPLICATIONS OF 2-SUBSTITUTED 4-HETEROARYLRYRIMIDINES | CYCLACEL LIMITED (GB) | 2004-07-08 | — | — | WO | claimed |
| CN-1503794-A | Inhiitors of cyclin dependent kinases as anti-cancer agent | — | 2004-06-09 | — | — | CN | claimed |
| EP-1373253-A1 | INHIBITORS OF CYCLIN DEPENDENT KINASES AS ANTI-CANCER AGENT | Cyclacel Limited (GB) | 2004-01-02 | — | — | EP | claimed |
| WO-2002079193-A1 | INHIBITORS OF CYCLIN DEPENDENT KINASES AS ANTI-CANCER AGENT | CYCLACEL LIMITED (GB) | 2002-10-10 | — | — | WO | claimed |
| CN-100519553-C | Inhiitors of cyclin dependent kinases as anti-cancer agent | CYCLACEL LTD (GB) | 2009-07-29 | — | — | CN | disclosed |
| CN-100425239-C | Therapeutic applications of 2-substituted 4-heteroarylpyrimidines | CYCLACEL LTD (GB) | 2008-10-15 | — | — | CN | disclosed |
| EP-1572211-B1 | THERAPEUTIC APPLICATIONS OF 2-SUBSTITUTED 4-HETEROARYLPYRIMIDINES | CYCLACEL LTD (GB) | 2008-02-20 | — | — | EP | disclosed |
| CN-1503794-A | Inhiitors of cyclin dependent kinases as anti-cancer agent | — | 2004-06-09 | — | — | CN | disclosed |
| EP-1373253-A1 | INHIBITORS OF CYCLIN DEPENDENT KINASES AS ANTI-CANCER AGENT | Cyclacel Limited (GB) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002079193-A1 | INHIBITORS OF CYCLIN DEPENDENT KINASES AS ANTI-CANCER AGENT | CYCLACEL LIMITED (GB) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282843-A1 | Therapeutic applications of 2-substituted 4-heteroarylpyrimidines | HRH2, HRH3, CYTH3 | CDK4 1254/4885CDK2 810/4885EIF2AK2 629/4885 |
| US-20070185134-A1 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CDK2, CCNK, CDK3 | CDK4 5/4885CDK2 1/4885EIF2AK2 831/4885 |
| US-20040132746-A1 | Inhibitors of cyclin dependent kinases as anti-cancer agent | CDK2, CCNK, CDK3 | CDK4 5/4885CDK2 1/4885EIF2AK2 831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.