Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | SIK1 | P57059 | 1/20 | 0.36 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.36 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586816 | 0.74 | KDR (0.39) | KDRKITFLT3MAP3K12SRC | |
| SCHEMBL4593901 | 0.74 | KDR (0.44) | KDRKITFLT3 | |
| SCHEMBL4587539 | 0.74 | KIT (0.68) | KDRKITFLT3SRC | |
| SCHEMBL4586176 | 0.73 | KIT (0.62) | KDRKITFLT3SRC | |
| SCHEMBL4586129 | 0.73 | KDR (0.41) | KDRKITFLT3 | |
| SCHEMBL4585514 | 0.72 | KDR (0.46) | KDR | |
| SCHEMBL4592951 | 0.72 | KDR (0.50) | KDR | |
| SCHEMBL4593275 | 0.72 | KIT (0.55) | KDRKITFLT3SRC | |
| SCHEMBL4586185 | 0.71 | KDR (0.37) | KDRKITFLT3MAP3K12SRC | |
| SCHEMBL4587497 | 0.71 | KDR (0.43) | KDRKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558609-A4 | KINASE INHIBITORS | MERCK & CO INC (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1558609-A2 | KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041164-A2 | KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | disclosed |