Known targets — ChEMBL curated mechanism
KCNA5KCND3KCNH2KCNJ3KCNJ5SCN5A
The experimentally established mechanism targets of Vernakalant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 known ✓ | P22460 | 6/20 | 1.00 |
| ▸ | SCN5A known ✓ | Q14524 | 6/20 | 1.00 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 1.00 |
| ▸ | KCND2 | Q9NZV8 | 5/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vernakalant SCHEMBL1762185 | 1.00 | KCNA5 (1.00) | KCNA5SCN5AKCND2KCNH2SLC6A4 | |
| Vernakalant SCHEMBL439144 | 1.00 | KCNA5 (1.00) | KCNA5SCN5AKCND2KCNH2SLC6A4 | |
| Vernakalant SCHEMBL441544 | 1.00 | KCNA5 (1.00) | KCNA5SCN5AKCND2KCNH2SLC6A4 | |
| Vernakalant SCHEMBL6276115 | 1.00 | KCNA5 (1.00) | KCNA5SCN5AKCND2KCNH2SLC6A4 | |
| Vernakalant SCHEMBL3338844 | 1.00 | KCNA5 (1.00) | KCNA5SCN5AKCND2KCNH2SLC6A4 | |
| Vernakalant SCHEMBL439679 | 1.00 | KCNA5 (1.00) | KCNA5SCN5AKCND2KCNH2SLC6A4 | |
| Vernakalant SCHEMBL439706 | 1.00 | KCNA5 (1.00) | KCNA5SCN5AKCND2KCNH2SLC6A4 | |
| Vernakalant SCHEMBL443797 | 1.00 | KCNA5 (1.00) | KCNA5SCN5AKCND2KCNH2SLC6A4 | |
| Vernakalant SCHEMBL442387 | 1.00 | KCNA5 (1.00) | KCNA5SCN5AKCND2KCNH2SLC6A4 | |
| Vernakalant SCHEMBL441030 | 1.00 | KCNA5 (1.00) | KCNA5SCN5AKCND2KCNH2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915340-A2 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | Cardiome Pharma Corp. (CA) | 2008-04-30 | — | — | EP | disclosed |
| WO-2006138673-A2 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2006-12-28 | — | — | WO | disclosed |
| EP-1560812-B1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP (CA) | 2006-05-10 | — | — | EP | disclosed |