Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 14/20 | 0.56 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.56 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4616094 | 0.88 | LPAR1 (0.55) | LPAR1LPAR5PTGDR2 | |
| SCHEMBL4635051 | 0.86 | PPARG (0.56) | LPAR1LPAR5 | |
| SCHEMBL14543897 | 0.85 | LPAR1 (0.52) | LPAR1LPAR5LPAR3ALOX5SLC2A1 | |
| SCHEMBL4616750 | 0.82 | PPARD (0.51) | LPAR1LPAR5PTGDR2 | |
| SCHEMBL5408677 | 0.81 | PPARG (0.57) | LPAR1LPAR5 | |
| SCHEMBL5422967 | 0.78 | LPAR1 (0.57) | LPAR1LPAR5LPAR3PTGDR2 | |
| SCHEMBL4616946 | 0.77 | LPAR1 (0.51) | LPAR1LPAR5 | |
| SCHEMBL4616341 | 0.77 | PPARD (0.64) | — | |
| SCHEMBL4616570 | 0.77 | LPAR1 (0.55) | LPAR1LPAR5 | |
| SCHEMBL14289659 | 0.76 | LPAR1 (0.45) | LPAR1LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697304-B1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | LILLY CO ELI (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1697304-A1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005054176-A1 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-06-16 | — | — | WO | disclosed |