SCHEMBL4616488

SCHEMBL4616488

Cc1c(C(=O)Nc2ccc(F)nc2)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(OCc2ccccc2)cc1.Cc1c(C(=O)O)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(OCc2ccccc2)cc1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 20/20 0.66
CNR2 P34972 10/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4897295 0.98 CNR1 (0.69) CNR1CNR2
SCHEMBL4614981 0.91 CNR1 (0.69) CNR1CNR2
SCHEMBL4904493 0.88 CNR1 (0.72) CNR1CNR2
SCHEMBL4617930 0.88 CNR1 (0.67) CNR1CNR2
SCHEMBL3080647 0.87 CNR1 (0.74) CNR1CNR2
SCHEMBL4618022 0.86 CNR1 (0.67) CNR1CNR2
SCHEMBL4893198 0.86 CNR1 (0.69) CNR1CNR2
SCHEMBL4617531 0.85 CNR1 (0.69) CNR1CNR2
SCHEMBL4903575 0.83 CNR1 (0.70) CNR1CNR2
SCHEMBL4617426 0.81 CNR1 (0.67) CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940820-A1 MIDAZOLE-4-CARBOXAMIDE DERIVATIVES FOR USE AS CB MODULATORS AstraZeneca AB (SE) 2008-07-09 EP disclosed
WO-2007031721-A1 MIDAZOLE-4-CARBOXAMIDE DERIVATIVES FOR USE AS CB MODULATORS ASTRAZENECA AB (SE) 2007-03-22 WO disclosed