Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 20/20 | 0.80 |
| ▸ | CCR3 | P51677 | 20/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4617323 | 0.90 | HRH1 (0.77) | HRH1CCR3KCNH2 | |
| SCHEMBL179983 | 0.89 | HRH1 (1.00) | HRH1CCR3KCNH2 | |
| SCHEMBL180281 | 0.89 | HRH1 (1.00) | HRH1CCR3KCNH2 | |
| SCHEMBL180056 | 0.87 | HRH1 (1.00) | HRH1CCR3KCNH2 | |
| SCHEMBL180057 | 0.87 | HRH1 (1.00) | HRH1CCR3KCNH2 | |
| SCHEMBL180099 | 0.85 | HRH1 (0.80) | HRH1CCR3KCNH2 | |
| SCHEMBL180079 | 0.85 | HRH1 (0.82) | HRH1CCR3KCNH2 | |
| SCHEMBL180201 | 0.83 | HRH1 (0.86) | HRH1CCR3KCNH2 | |
| SCHEMBL5194236 | 0.83 | HRH1 (0.67) | HRH1CCR3KCNH2 | |
| SCHEMBL180030 | 0.81 | HRH1 (0.64) | HRH1CCR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888526-A1 | PIPERIDINES FOR THE TREATMENT OF CHEMOKINE MEDIATED DISEASES | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006126947-A1 | PIPERIDINES FOR THE TREATMENT OF CHEMOKINE MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |