Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 14/20 | 0.45 |
| ▸ | HTR3A | P46098 | 7/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.43 |
| ▸ | HTR3B | O95264 | 4/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL492138 | 1.00 | CHRNA7 (0.45) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL492146 | 0.91 | CHRNA7 (0.45) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL4616084 | 0.91 | CHRNA7 (0.45) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL492198 | 0.86 | CHRNA7 (0.46) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL1966264 | 0.84 | CHRNA7 (0.45) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL1963294 | 0.84 | CHRNA7 (0.44) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL492738 | 0.83 | CHRNA7 (0.43) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL4728313 | 0.83 | CHRNA7 (0.43) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL1965697 | 0.83 | CHRNA7 (0.42) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5996850 | 0.83 | CHRNA7 (0.42) | CHRNA7HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940833-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007038367-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-04-05 | — | — | WO | claimed |