Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PTGIR | P43119 | 3/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8075339 | 0.80 | POLB (0.68) | POLBTP53ALDH1A1CES2CES1 | |
| SCHEMBL1118601 | 0.79 | PTGIR (0.49) | POLBPTGIRESR1ESR2KDM4E | |
| SCHEMBL2093031 | 0.79 | PTGIR (0.51) | POLBPTGIRESR1ESR2KDM4E | |
| SCHEMBL2093029 | 0.77 | PTGIR (0.50) | POLBPTGIRESR1ESR2KDM4E | |
| SCHEMBL1118734 | 0.76 | PTGIR (0.48) | POLBTP53PTGIRALDH1A1KAT6A | |
| SCHEMBL11674348 | 0.72 | POLB (0.66) | POLBTP53ALDH1A1CES2CES1 | |
| SCHEMBL3834690 | 0.72 | POLB (0.61) | POLBTP53ALDH1A1CES2CES1 | |
| SCHEMBL5058365 | 0.70 | PTGIR (0.50) | PTGIRESR1ESR2KDM4ECES2 | |
| SCHEMBL2090910 | 0.70 | PTGIR (0.59) | POLBPTGIRALDH1A1MEN1KMT2A | |
| SCHEMBL2090908 | 0.70 | PTGIR (0.50) | PTGIRESR1ESR2KDM4ECES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940792-A2 | AMINOPYRIMIDINE, AMINOPYRIDINE AND ANILINE DERIVATIVES INHIBITORS OF PIM-1 AND/OR PIM-3 | Exelixis, Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007044724-A2 | AMINOPYRIMIDINE, AMINOPYRIDINE AND ANILINE DERIVATIVES INHIBITORS OF PIM-I AND/OR PIM-3 | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |