Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.76 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.76 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.76 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.76 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.76 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL458032 | 1.00 | PIK3CD (0.76) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL16266146 | 0.87 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL660510 | 0.87 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL29394358 | 0.87 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL657898 | 0.87 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL16266140 | 0.87 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL173490 | 0.87 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL461788 | 0.86 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL470241 | 0.83 | PIK3CD (0.79) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL13075389 | 0.83 | PIK3CD (0.79) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613781-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032065-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GLAXO GROUP LIMITED (GB) | 2012-03-15 | — | — | WO | disclosed |