Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 17/20 | 0.61 |
| ▸ | EGFR | P00533 | 7/20 | 0.48 |
| ▸ | FECH | P22830 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174516 | 0.93 | ERBB2 (0.59) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL6177811 | 0.92 | ERBB2 (0.52) | ERBB2EGFRERBB4HDAC1HDAC6 | |
| SCHEMBL6171500 | 0.92 | ERBB2 (0.63) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL6173689 | 0.91 | ERBB2 (0.62) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4618703 | 0.91 | ERBB2 (0.62) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL6175317 | 0.91 | ERBB2 (0.62) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4619123 | 0.91 | ERBB2 (0.73) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL6174949 | 0.91 | ERBB2 (0.61) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL6174991 | 0.90 | ERBB2 (0.60) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL6186159 | 0.90 | ERBB2 (0.62) | ERBB2EGFRFECHCDK8MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194596-A1 | Therapeutic Combination Including a Selective Erbb2 Inhibitor | FRIZER INC. | 2008-08-14 | — | — | US | claimed |
| EP-1896030-A1 | COMBINATIONS OF ERBB2 INHIBITORS WITH OTHER THERAPEUTIC AGENTS IN THE TREATMENT OF CANCER | Pfizer Products Incorporated (US) | 2008-03-12 | — | — | EP | claimed |
| EP-1448551-B1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | OSI PHARM INC (US) | 2007-10-31 | — | — | EP | claimed |
| WO-2006129163-A1 | COMBINATIONS OF ERBB2 INHIBITORS WITH OTHER THERAPEUTIC AGENTS IN THE TREATMENT OF CANCER | PFIZER PRODUCTS INC. (US) | 2006-12-07 | — | — | WO | claimed |
| EP-1682176-A1 | SELECTIVE ERBB2 INHIBITOR/ANTI-ERBB ANTIBODY COMBINATIONS IN THE TREATMENT OF CANCER | Pfizer Products Inc. (US) | 2006-07-26 | — | — | EP | claimed |
| EP-1658080-A1 | DOSING SCHEDULE FOR A ERBB2 ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2006-05-24 | — | — | EP | claimed |
| US-20050159435-A1 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER INC | 2005-07-21 | — | — | US | claimed |
| US-20050119288-A1 | Dosing schedule for a novel anticancer agent | PFIZER INC | 2005-06-02 | — | — | US | claimed |
| WO-2005044302-A1 | SELECTIVE ERBB2 INHIBITOR/ANTI-ERBB ANTIBODY COMBINATIONS IN THE TREATMENT OF CANCER | PFIZER PRODUCTS INC. (US) | 2005-05-19 | — | — | WO | claimed |
| US-20050101618-A1 | Selective erbB2 inhibitor/anti-erbB antibody combinations in the treatment of cancer | PFIZER INC | 2005-05-12 | — | — | US | claimed |
| US-6890924-B2 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER INC (US) | 2005-05-10 | — | — | US | claimed |
| WO-2005016347-A1 | DOSING SCHEDULE FOR ERBB2 ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2005-02-24 | — | — | WO | claimed |
| EP-1292591-B1 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PROD INC (US) | 2005-02-02 | — | — | EP | claimed |
| EP-1448551-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2004-08-25 | — | — | EP | claimed |
| US-20030171386-A1 | Small molecules for the treatment of abnormal cell growth | PFIZER INC. | 2003-09-11 | — | — | US | claimed |
| US-20030144506-A1 | Processes for the preparation of substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER INC. | 2003-07-31 | — | — | US | claimed |
| WO-2003045939-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2003-06-05 | — | — | WO | claimed |
| EP-1292591-A2 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2003-03-19 | — | — | EP | claimed |
| WO-2001098277-A2 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2001-12-27 | — | — | WO | claimed |
| US-20080194596-A1 | Therapeutic Combination Including a Selective Erbb2 Inhibitor | FRIZER INC. | 2008-08-14 | — | — | US | disclosed |
| EP-1896030-A1 | COMBINATIONS OF ERBB2 INHIBITORS WITH OTHER THERAPEUTIC AGENTS IN THE TREATMENT OF CANCER | Pfizer Products Incorporated (US) | 2008-03-12 | — | — | EP | disclosed |
| US-7332493-B2 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | OSI PHARMACEUTICALS (US) | 2008-02-19 | — | — | US | disclosed |
| EP-1740184-A1 | COMBINATIONS OF SIGNAL TRANSDUCTION INHIBITORS | Pfizer Products Incorporated (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2006129163-A1 | COMBINATIONS OF ERBB2 INHIBITORS WITH OTHER THERAPEUTIC AGENTS IN THE TREATMENT OF CANCER | PFIZER PRODUCTS INC. (US) | 2006-12-07 | — | — | WO | disclosed |
| EP-1658080-A1 | DOSING SCHEDULE FOR A ERBB2 ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005094830-A1 | COMBINATIONS OF SIGNAL TRANSDUCTION INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-10-13 | — | — | WO | disclosed |
| US-20050222163-A1 | Combinations of signal transduction inhibitors | PFIZER INC | 2005-10-06 | — | — | US | disclosed |
| US-20050159435-A1 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER INC | 2005-07-21 | — | — | US | disclosed |
| US-20050119288-A1 | Dosing schedule for a novel anticancer agent | PFIZER INC | 2005-06-02 | — | — | US | disclosed |
| US-20050101618-A1 | Selective erbB2 inhibitor/anti-erbB antibody combinations in the treatment of cancer | PFIZER INC | 2005-05-12 | — | — | US | disclosed |
| US-6890924-B2 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER INC (US) | 2005-05-10 | — | — | US | disclosed |
| WO-2005016347-A1 | DOSING SCHEDULE FOR ERBB2 ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2005-02-24 | — | — | WO | disclosed |
| EP-1292591-B1 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PROD INC (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-1465632-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| EP-1448551-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2004-08-25 | — | — | EP | disclosed |
| US-20030171386-A1 | Small molecules for the treatment of abnormal cell growth | PFIZER INC. | 2003-09-11 | — | — | US | disclosed |
| US-20030144506-A1 | Processes for the preparation of substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER INC. | 2003-07-31 | — | — | US | disclosed |
| WO-2003049740-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2003-06-19 | — | — | WO | disclosed |
| WO-2003045939-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2003-06-05 | — | — | WO | disclosed |
| EP-1292591-A2 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Inc. (US) | 2003-03-19 | — | — | EP | disclosed |
| US-20020169165-A1 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER PRODUCTS INC. | 2002-11-14 | — | — | US | disclosed |
| WO-2001098277-A2 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2001-12-27 | — | — | WO | disclosed |
| WO-2001098277-A2 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2001-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169165-A1 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | CCNA1, CCNT1, CCNB1 | ERBB2 755/4885EGFR 119/4885FECH 3297/4885 |
| US-20050101618-A1 | Selective erbB2 inhibitor/anti-erbB antibody combinations in the treatment of cancer | ERBB2, ERBB3, EGFR | ERBB2 1/4885EGFR 3/4885FECH 3716/4885 |
| US-20050119288-A1 | Dosing schedule for a novel anticancer agent | ERBB2, ERBB3, EGFR | ERBB2 1/4885EGFR 3/4885FECH 4515/4885 |
| US-20080194596-A1 | Therapeutic Combination Including a Selective Erbb2 Inhibitor | ERBB2, ERBB3, EGFR | ERBB2 1/4885EGFR 3/4885FECH 3926/4885 |
| US-20050159435-A1 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | CCNA1, CCNT1, CCNB1 | ERBB2 883/4885EGFR 164/4885FECH 2655/4885 |
| US-20030171386-A1 | Small molecules for the treatment of abnormal cell growth | ERBB2, EGFR, ERBB3 | ERBB2 1/4885EGFR 2/4885FECH 4706/4885 |
| US-20030144506-A1 | Processes for the preparation of substituted bicyclic derivatives for the treatment of abnormal cell growth | CCNA1, CCNE1, CCNT1 | ERBB2 1149/4885EGFR 148/4885FECH 3419/4885 |
| US-20050222163-A1 | Combinations of signal transduction inhibitors | CDK4, CDK3, CDK2 | ERBB2 105/4885EGFR 152/4885FECH 3680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.