Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 6/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.63 |
| ▸ | USP7 | Q93009 | 3/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | ATR | Q13535 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1679753 | 0.86 | FYN (0.68) | FYNKCNH2 | |
| SCHEMBL20485814 | 0.85 | FYN (1.00) | FYNKCNH2ATRLRRK2 | |
| SCHEMBL30521848 | 0.85 | FYN (1.00) | FYNKCNH2ATRLRRK2 | |
| SCHEMBL1678990 | 0.82 | FYN (0.69) | FYNKCNH2ADORA2AATRLRRK2 | |
| SCHEMBL18617157 | 0.82 | FYN (0.66) | FYNKCNH2ADORA2AATRMAP4K4 | |
| SCHEMBL25619799 | 0.81 | FYN (0.72) | FYNUSP7MAP4K4 | |
| SCHEMBL4620367 | 0.80 | FYN (0.76) | FYNUSP7MAP4K4 | |
| SCHEMBL2749343 | 0.79 | FYN (0.62) | FYNKCNH2ADORA2AATRLRRK2 | |
| SCHEMBL2386280 | 0.78 | FYN (0.60) | FYNKCNH2ADORA2AATRLRRK2 | |
| SCHEMBL2384703 | 0.78 | FYN (0.60) | FYNKCNH2ADORA2AATRLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |