Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.64 |
| ▸ | FYN | P06241 | 5/20 | 0.60 |
| ▸ | ATR | Q13535 | 1/20 | 0.51 |
| ▸ | USP7 | Q93009 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4620369 | 0.82 | USP7 (0.73) | CHEK2FYNUSP7MAP4K4 | |
| SCHEMBL12489152 | 0.82 | CHEK2 (0.71) | CHEK2FYNUSP7MKNK1MAP4K4 | |
| SCHEMBL8225016 | 0.81 | CYP2A6 (0.62) | MEN1PSIP1AXLMKNK1MKNK2 | |
| SCHEMBL4620478 | 0.78 | CHEK2 (1.00) | CHEK2FYNMKNK1MAP4K4 | |
| SCHEMBL18263126 | 0.76 | FYN (0.58) | CHEK2FYNATRUSP7MAP4K4 | |
| SCHEMBL4470993 | 0.76 | CHEK2 (0.56) | CHEK2FYNUSP7MEN1VRK1 | |
| SCHEMBL16835804 | 0.76 | FYN (0.52) | CHEK2FYNATRMEN1PSIP1 | |
| SCHEMBL17011907 | 0.76 | CHEK2 (0.63) | CHEK2FYNUSP7MKNK1MKNK2 | |
| SCHEMBL26916929 | 0.75 | CHEK2 (0.55) | CHEK2FYNUSP7MEN1PSIP1 | |
| SCHEMBL29582616 | 0.75 | CHEK2 (0.55) | CHEK2FYNUSP7MEN1PSIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |