Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 13/20 | 0.57 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | QPCT | Q16769 | 1/20 | 0.43 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16675754 | 0.89 | QPCT (0.51) | FYNPTGES2CTSLQPCTQPCTL | |
| SCHEMBL4727204 | 0.84 | PTGES2 (0.47) | FYNPTGES2QPCTQPCTLMAP4K4 | |
| SCHEMBL978966 | 0.77 | QPCT (0.53) | FYNPTGES2QPCTQPCTLMAP4K4 | |
| SCHEMBL15349707 | 0.75 | PRKCI (0.51) | FYNCHEK2 | |
| SCHEMBL3767625 | 0.73 | QPCT (0.54) | PTGES2QPCTQPCTLKDM4EMEN1 | |
| SCHEMBL20486031 | 0.73 | FYN (1.00) | FYNMAP4K4CHEK2 | |
| SCHEMBL30521703 | 0.73 | FYN (1.00) | FYNMAP4K4CHEK2 | |
| SCHEMBL18613247 | 0.72 | FYN (1.00) | FYN | |
| SCHEMBL30521820 | 0.72 | FYN (1.00) | FYN | |
| SCHEMBL3660129 | 0.72 | DYRK1A (0.57) | FYNPTGES2QPCTQPCTLCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |