Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4619727 | 0.87 | ATM (0.36) | MAPT | |
| SCHEMBL2205238 | 0.82 | KDM4E (0.37) | KDM4EGAAMAPT | |
| SCHEMBL4620417 | 0.78 | KDM4E (0.38) | KDM4EGAAMAPT | |
| SCHEMBL2205084 | 0.77 | MAPT (0.41) | KDM4EGAAMAPT | |
| SCHEMBL4620016 | 0.75 | — | — | |
| SCHEMBL6409412 | 0.71 | — | — | |
| SCHEMBL4620794 | 0.68 | CYP19A1 (0.42) | MAPT | |
| SCHEMBL2209410 | 0.67 | ATM (0.39) | MAPT | |
| SCHEMBL2208839 | 0.67 | ATM (0.39) | MAPT | |
| SCHEMBL4066532 | 0.67 | TSHR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888542-A1 | SUBSTITUTED SPIRO-COMPOUNDS AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006136245-A1 | SUBSTITUTED SPIRO-COMPOUNDS AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | Grünenthal GmbH (DE) | 2006-12-28 | — | — | WO | disclosed |