Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 7/20 | 0.89 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.76 |
| ▸ | ESR1 | P03372 | 11/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.73 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | TP53 | P04637 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | EGFR | P00533 | 1/20 | 0.72 |
| ▸ | GBA1 | P04062 | 1/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.72 |
| ▸ | PRKCG | P05129 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11370966 | 1.00 | CYP19A1 (0.89) | CYP19A1CYP3A4ESR1NR1I2ESR2 | |
| SCHEMBL4620164 | 1.00 | CYP19A1 (0.89) | CYP19A1CYP3A4ESR1NR1I2ESR2 | |
| SCHEMBL31167386 | 0.94 | CYP19A1 (1.00) | CYP19A1CYP3A4ESR1ESR2MAPT | |
| SCHEMBL11254955 | 0.92 | CYP19A1 (0.77) | CYP19A1CYP3A4ESR1NR1I2ESR2 | |
| SCHEMBL16579225 | 0.89 | CYP19A1 (0.78) | CYP19A1CYP3A4ESR1NR1I2ESR2 | |
| SCHEMBL84895 | 0.89 | CYP19A1 (0.78) | CYP19A1CYP3A4ESR1NR1I2ESR2 | |
| SCHEMBL14136921 | 0.88 | CYP19A1 (0.71) | CYP19A1CYP3A4ESR1NR1I2ESR2 | |
| SCHEMBL3817784 | 0.88 | NR1I2 (0.73) | CYP19A1CYP3A4ESR1NR1I2ESR2 | |
| SCHEMBL3813077 | 0.88 | CYP19A1 (0.89) | CYP19A1CYP3A4ESR1NR1I2ESR2 | |
| Desmethyl Tamoxifen SCHEMBL1110844 | 0.86 | CYP19A1 (1.00) | CYP19A1CYP3A4ESR1NR1I2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889639-A2 | Methods and compositions containing succinimide or maleimide derivatives of antineoplastic agents, for producing long lasting antineoplastic agents | ConjuChem Biotechnologies Inc. (CA) | 2008-02-20 | — | — | EP | disclosed |
| EP-1212120-A2 | METHODS AND COMPOSITIONS CONTAINING SUCCINIMIDE OR MALEIMIDE DERIVATIVES OF ANTINEOPLASTIC AGENTS, FOR PRODUCING LONG LASTING ANTINEOPLASTIC AGENTS | Conjuchem, Inc. (CA) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001017614-A2 | METHODS AND COMPOSITIONS CONTAINING SUCCINIMIDE OR MALEIMIDE DERIVATIVES OF ANTINEOPLASTIC AGENTS | CONJUCHEM, INC. (CA) | 2001-03-15 | — | — | WO | disclosed |