Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 10/20 | 0.70 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.59 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.54 |
| ▸ | USP7 | Q93009 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18613233 | 0.82 | FYN (1.00) | FYNCHEK2TGFBR1 | |
| SCHEMBL18613475 | 0.81 | FYN (1.00) | FYNMAP4K4CHEK2CHEK1 | |
| SCHEMBL20486031 | 0.80 | FYN (1.00) | FYNMAP4K4CHEK2USP7CHEK1 | |
| SCHEMBL30521703 | 0.80 | FYN (1.00) | FYNMAP4K4CHEK2USP7CHEK1 | |
| SCHEMBL18613268 | 0.78 | FYN (1.00) | FYNMAP4K4CHEK2CHEK1 | |
| SCHEMBL30521908 | 0.78 | FYN (1.00) | FYNMAP4K4CHEK2CHEK1 | |
| SCHEMBL18613246 | 0.75 | FYN (1.00) | FYNMAP4K4CHEK2USP7CHEK1 | |
| SCHEMBL29508267 | 0.75 | MAP4K4 (1.00) | MAP4K4CYP1A2KCNH2MINK1TNIK | |
| SCHEMBL19048531 | 0.70 | MAP4K4 (0.59) | FYNMAP4K4CYP1A2KCNH2MINK1 | |
| SCHEMBL2682065 | 0.69 | SLC2A1 (0.67) | FYNMAP4K4CYP1A2KCNH2MINK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |