Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 8/20 | 0.70 |
| ▸ | CHEK2 | O96017 | 8/20 | 0.62 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.56 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.56 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | USP7 | Q93009 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4620367 | 0.90 | FYN (0.76) | FYNCHEK2MKNK1MAP4K4CHEK1 | |
| SCHEMBL13977197 | 0.83 | CHEK2 (0.66) | FYNCHEK2MKNK1MAP4K4CHEK1 | |
| SCHEMBL13968138 | 0.83 | FYN (0.69) | FYNCHEK2MKNK1MAP4K4CHEK1 | |
| SCHEMBL30521785 | 0.83 | FYN (1.00) | FYNCHEK2MKNK1MAP4K4 | |
| SCHEMBL18613286 | 0.83 | FYN (1.00) | FYNCHEK2MKNK1MAP4K4 | |
| SCHEMBL1679739 | 0.82 | FYN (0.81) | FYNCHEK2MKNK1CHEK1 | |
| SCHEMBL1679092 | 0.81 | FYN (0.80) | FYNCHEK2TGFBR1CHEK1 | |
| SCHEMBL1147444 | 0.81 | PARP1 (0.77) | FYNPARP1 | |
| SCHEMBL1679160 | 0.81 | FYN (0.63) | FYNCHEK2MKNK1MAP4K4CHEK1 | |
| SCHEMBL2224294 | 0.80 | FYN (0.72) | FYNCHEK2MKNK1MAP4K4CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |