Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.49 |
| ▸ | XDH | P47989 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5417604 | 0.99 | ESR1 (0.54) | ESR1ESR2XDH | |
| SCHEMBL14506970 | 0.91 | ESR1 (0.55) | ESR1ESR2XDH | |
| SCHEMBL5422322 | 0.91 | ESR1 (0.55) | ESR1ESR2XDH | |
| SCHEMBL5422430 | 0.90 | ESR1 (0.53) | ESR1 | |
| SCHEMBL14428679 | 0.90 | ESR1 (0.58) | ESR1ESR2XDH | |
| SCHEMBL503003 | 0.89 | ESR1 (0.58) | ESR1ESR2XDH | |
| SCHEMBL4619222 | 0.88 | ESR1 (0.55) | ESR1ESR2XDH | |
| SCHEMBL5416855 | 0.87 | ESR1 (0.54) | ESR1ESR2XDH | |
| SCHEMBL4621568 | 0.87 | ESR1 (0.55) | ESR1ESR2XDH | |
| SCHEMBL4641975 | 0.86 | ESR1 (0.68) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899316-A1 | BENZOPYRANONE COMPOUNDS FOR TREATING CANCER | Signal Pharmaceuticals LLC (US) | 2008-03-19 | — | — | EP | disclosed |
| US-20070191343-A1 | 4-((4-(2-Azaperhydroepinylethoxy)phenyl)methyl)-3-2(2,4-dichlorophenyl)-7-hydroxychromen-2-one, pharmaceutically acceptable salts thereof and methods of use therewith | SIGNAL PHARMACEUTICALS, LLC | 2007-08-16 | — | — | US | disclosed |
| US-20070123511-A1 | Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer | SIGNAL PHARMACEUTICALS LLC | 2007-05-31 | — | — | US | disclosed |
| WO-2007002272-A1 | BENZOPYRANONE COMPOUNDS FOR TREATING CANCER | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007002272-A1 | BENZOPYRANONE COMPOUNDS FOR TREATING CANCER | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123511-A1 | Benzopyranone compounds, compositions thereof, and methods for treating or preventing cancer | BRCA1, RB1, TP53 | ESR1 343/4885ESR2 515/4885XDH 354/4885 |
| US-20070191343-A1 | 4-((4-(2-Azaperhydroepinylethoxy)phenyl)methyl)-3-2(2,4-dichlorophenyl)-7-hydroxychromen-2-one, pharmaceutically acceptable salts thereof and methods of use therewith | CYP3A43, CYP2D6, CYP2J2 | ESR1 697/4885ESR2 406/4885XDH 531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.