Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 6/20 | 0.80 |
| ▸ | ITGAM | P11215 | 6/20 | 0.80 |
| ▸ | SLC1A3 | P43003 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | CASP3 | P42574 | 1/20 | 0.66 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.66 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.66 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 2/20 | 0.59 |
| ▸ | BAG3 | O95817 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683059 | 0.89 | ITGB2 (1.00) | ITGB2ITGAMSLC1A3MEN1KMT2A | |
| SCHEMBL46561 | 0.84 | ITGB2 (1.00) | ITGB2ITGAMSLC1A3MEN1KMT2A | |
| SCHEMBL46577 | 0.83 | SLC1A3 (0.88) | ITGB2ITGAMSLC1A3MEN1KMT2A | |
| SCHEMBL5147456 | 0.83 | SLC1A3 (0.88) | ITGB2ITGAMSLC1A3MEN1KMT2A | |
| SCHEMBL5145237 | 0.82 | SLC1A3 (1.00) | ITGB2ITGAMSLC1A3MEN1KMT2A | |
| SCHEMBL5145242 | 0.82 | SLC1A3 (1.00) | ITGB2ITGAMSLC1A3MEN1KMT2A | |
| SCHEMBL21337634 | 0.81 | SLC1A3 (0.82) | ITGB2ITGAMSLC1A3MEN1KMT2A | |
| SCHEMBL46558 | 0.81 | ITGB2 (1.00) | ITGB2ITGAMSLC1A3MEN1KMT2A | |
| SCHEMBL5166105 | 0.81 | ITGB2 (0.68) | ITGB2ITGAMSLC1A3MEN1KMT2A | |
| SCHEMBL5166114 | 0.81 | ITGB2 (0.68) | ITGB2ITGAMSLC1A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012005800-A1 | COMPOUNDS AND METHODS FOR REGULATING INTEGRIN CD11B/CD18 | ADHAERE PHARAMACEUTICALS, INC. (US) | 2012-01-12 | — | — | WO | disclosed |