Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | CCR9 | P51686 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GNRHR | P30968 | 2/20 | 0.30 |
| ▸ | EDNRB | P24530 | 1/20 | 0.30 |
| ▸ | EDNRA | P25101 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4226409 | 0.91 | IRAK4 (0.35) | IRAK4POLBSYKGNRHRHPGD | |
| SCHEMBL4229030 | 0.91 | EDNRA (0.33) | POLBNR1I2EDNRBEDNRA | |
| SCHEMBL4232018 | 0.88 | IRAK4 (0.43) | IRAK4POLBMDM2SYKIRAK1 | |
| SCHEMBL4621267 | 0.86 | GRM4 (0.36) | NR1I2EDNRBEDNRA | |
| SCHEMBL13743435 | 0.85 | GNRHR (0.35) | POLBNR1I2GNRHRHPGDCACNA1F | |
| SCHEMBL4231634 | 0.84 | GNRHR (0.42) | POLBGAAGNRHRHPGDCACNA1F | |
| SCHEMBL4236457 | 0.84 | SYK (0.36) | IRAK4POLBSYKIRAK1GNRHR | |
| SCHEMBL4231659 | 0.83 | NR1I2 (0.33) | POLBNR1I2 | |
| SCHEMBL4233491 | 0.83 | GRM4 (0.38) | POLBNR1I2 | |
| SCHEMBL4233369 | 0.83 | GNRHR (0.36) | GAAGNRHRHPGDCACNA1FCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896465-A1 | HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS | Takeda Cambridge Limited (GB) | 2008-03-12 | — | — | EP | claimed |
| WO-2007000582-A1 | HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS | TAKEDA CAMBRIDGE LIMITED (GB) | 2007-01-04 | — | — | WO | claimed |