Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 6/20 | 0.71 |
| ▸ | CHEK2 | O96017 | 11/20 | 0.67 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12516852 | 0.86 | CHEK2 (0.88) | FYNCHEK2MKNK1MAP4K4CHEK1 | |
| SCHEMBL18613241 | 0.83 | FYN (1.00) | FYNCHEK2MKNK1MAP4K4CHEK1 | |
| SCHEMBL2224862 | 0.82 | CHEK2 (0.72) | FYNCHEK2MKNK1MAP4K4CHEK1 | |
| SCHEMBL18613256 | 0.81 | FYN (1.00) | FYNCHEK2MAP4K4 | |
| SCHEMBL18613577 | 0.81 | FYN (1.00) | FYNCHEK2MAP4K4 | |
| SCHEMBL4620246 | 0.81 | CHEK2 (1.00) | FYNCHEK2MKNK1MAP4K4CHEK1 | |
| SCHEMBL13977050 | 0.80 | CHEK2 (0.77) | FYNCHEK2MKNK1MAP4K4CHEK1 | |
| SCHEMBL12078349 | 0.78 | CHEK2 (0.72) | FYNCHEK2MKNK1MAP4K4CHEK1 | |
| SCHEMBL2228006 | 0.78 | CHEK2 (0.75) | FYNCHEK2MKNK1MAP4K4CHEK1 | |
| SCHEMBL2225807 | 0.78 | MAP4K4 (1.00) | FYNCHEK2MKNK1MAP4K4CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | claimed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | claimed |
| EP-1900727-A1 | Aminopyridine derivatives as kinase inhibitors | CELLZOME AG (DE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2008025820-A1 | AMINOPYRIDINE DERIVATES AS KINASE INHIBITORS | CELLZOME LIMITED (GB) | 2008-03-06 | — | — | WO | disclosed |