Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.45 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paraben SCHEMBL9839132 | 0.88 | PLK1 (0.53) | TSHRSLC16A3PLK1PLK3 | |
| SCHEMBL29424595 | 0.87 | FOLH1 (0.66) | TSHRFOLH1CA12CA1CA2 | |
| SCHEMBL241263 | 0.87 | FOLH1 (0.66) | TSHRFOLH1CA12CA1CA2 | |
| SCHEMBL11707462 | 0.86 | TSHR (0.62) | TSHRFOLH1SLC16A3RXRAPLK1 | |
| Ammonia Solution, Strong SCHEMBL7713420 | 0.85 | FOLH1 (0.63) | TSHRFOLH1CA12CA1CA2 | |
| Ammonia Solution, Strong SCHEMBL7713422 | 0.85 | FOLH1 (0.63) | TSHRFOLH1CA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL3180119 | 0.85 | FOLH1 (0.63) | TSHRFOLH1CA12CA1CA2 | |
| Bromide SCHEMBL3182496 | 0.85 | FOLH1 (0.63) | TSHRFOLH1CA12CA1CA2 | |
| SCHEMBL27691698 | 0.85 | FOLH1 (0.63) | TSHRFOLH1CA12CA1CA2 | |
| SCHEMBL27904905 | 0.85 | FOLH1 (0.63) | TSHRFOLH1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381380-B1 | PHARMACEUTICAL COMPOSITION CONTAINING BULBOPHYLLUM | BARTHEL MICHAEL (LI) | 2008-01-02 | — | — | EP | disclosed |
| EP-1381380-A1 | PHARMACEUTICAL COMPOSITION CONTAINING BULBOPHYLLUM | Barthel, Michael (LI) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002087601-A1 | PHARMACEUTICAL COMPOSITION CONTAINING BULBOPHYLLUM | BARTHEL MICHAEL (LI) | 2002-11-07 | — | — | WO | disclosed |