Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15897961 | 0.82 | ROCK1 (1.00) | ROCK1HDAC8HDAC6MAPTRAB9A | |
| SCHEMBL4252909 | 0.80 | HDAC8 (0.76) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL2565238 | 0.80 | HDAC8 (0.76) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL1662743 | 0.80 | HDAC8 (0.68) | ROCK1HDAC8HDAC6MAPTRAB9A | |
| SCHEMBL15880218 | 0.79 | ROCK1 (0.74) | ROCK1HDAC8HDAC6MAPTRAB9A | |
| SCHEMBL4620979 | 0.78 | HDAC8 (0.63) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL4617588 | 0.78 | HDAC8 (0.63) | HDAC8HDAC6RAB9ANPC1MEN1 | |
| SCHEMBL4617955 | 0.78 | HDAC8 (0.68) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL4619469 | 0.78 | HDAC8 (0.63) | HDAC8HDAC6MAPTRAB9ANPC1 | |
| SCHEMBL8770431 | 0.78 | HDAC8 (0.81) | HDAC8HDAC6MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889830-A1 | Biarylcarboxyarylamides as vanilloid-1 receptor modulators | Pharmeste S.r.l. (IT) | 2008-02-20 | — | — | EP | claimed |
| EP-1889830-A1 | Biarylcarboxyarylamides as vanilloid-1 receptor modulators | Pharmeste S.r.l. (IT) | 2008-02-20 | — | — | EP | disclosed |