SCHEMBL4623488

SCHEMBL4623488

CN[C@H]1CC[C@H](N(CCN2CCCC2)S(=O)(=O)c2ccc(Nc3nccc(Nc4ccc(F)cc4)n3)cc2)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.43
MEN1 O00255 1/20 0.43
NPC1 O15118 1/20 0.43
LMNA P02545 1/20 0.43
ALOX12 P18054 1/20 0.43
MAPK1 P28482 1/20 0.43
RAB9A P51151 1/20 0.43
KMT2A Q03164 1/20 0.43
IGF1R P08069 5/20 0.39
CDK2 P24941 4/20 0.39
EGFR P00533 1/20 0.39
INSR P06213 1/20 0.39
MET P08581 1/20 0.39
KDR P35968 1/20 0.39
TEK Q02763 1/20 0.39
RXFP1 Q9HBX9 1/20 0.38
SRC P12931 2/20 0.37
AURKA O14965 1/20 0.37
CDK1 P06493 1/20 0.37
CCNB1 P14635 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14020269 1.00 MAPT (0.43) MAPTMEN1NPC1LMNAALOX12
SCHEMBL4648085 1.00 MAPT (0.43) MAPTMEN1NPC1LMNAALOX12
SCHEMBL4623410 0.91 MAPT (0.46) MAPTMEN1NPC1LMNAALOX12
SCHEMBL4623127 0.90 MAPT (0.45) MAPTMEN1NPC1LMNAALOX12
SCHEMBL4623130 0.90 MAPT (0.45) MAPTMEN1NPC1LMNAALOX12
SCHEMBL14020246 0.90 MAPT (0.45) MAPTMEN1NPC1LMNAALOX12
SCHEMBL4623421 0.89 MAPT (0.46) MAPTMEN1NPC1LMNAALOX12
SCHEMBL4622764 0.89 MAPT (0.45) MAPTMEN1NPC1LMNAALOX12
SCHEMBL4621447 0.89 MAPT (0.45) MAPTMEN1NPC1LMNAALOX12
SCHEMBL4651587 0.89 MAPT (0.45) MAPTMEN1NPC1LMNAALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1904479-A2 NOVEL 2,4-DIANILINOPYRIMIDINE DERIVATIVES, THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, AS IKK INHIBITORS Sanofi-Aventis (FR) 2008-04-02 EP disclosed
WO-2007006926-A2 NOVEL 2,4-DIANILINOPYRIMIDINE DERIVATIVES, THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, AS IKK INHIBITORS SANOFI-AVENTIS (FR) 2007-01-18 WO disclosed