Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL469724 | 0.89 | NTRK1 (0.68) | NTRK1JAK2 | |
| SCHEMBL462674 | 0.88 | NTRK1 (0.67) | NTRK1JAK2 | |
| SCHEMBL462965 | 0.87 | NTRK1 (0.79) | NTRK1JAK2 | |
| SCHEMBL460457 | 0.85 | NTRK1 (0.64) | NTRK1JAK2 | |
| SCHEMBL457461 | 0.85 | NTRK1 (0.79) | NTRK1JAK2 | |
| SCHEMBL2691801 | 0.80 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL469892 | 0.80 | NTRK1 (0.81) | NTRK1JAK2 | |
| SCHEMBL2691800 | 0.80 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL29794653 | 0.80 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL14897510 | 0.80 | SMPD3 (0.69) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034095-A1 | COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | claimed |
| WO-2012034095-A1 | COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | disclosed |
| WO-2012034095-A1 | COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | disclosed |