Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5514832 | 0.93 | HPGD (0.65) | HPGDEPHX1L3MBTL3L3MBTL1RECQL | |
| SCHEMBL3160275 | 0.93 | HPGD (0.65) | HPGDEPHX1L3MBTL3L3MBTL1RECQL | |
| SCHEMBL17128329 | 0.91 | HPGD (0.62) | HPGDEPHX1L3MBTL3L3MBTL1RECQL | |
| SCHEMBL2165760 | 0.90 | HPGD (0.50) | HPGDEPHX1RECQLKDM4EMAPT | |
| SCHEMBL24183612 | 0.88 | HPGD (0.64) | HPGDEPHX1L3MBTL3L3MBTL1RECQL | |
| Hydrochloric Acid SCHEMBL3278700 | 0.88 | HPGD (0.49) | HPGDEPHX1RECQLKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL3962545 | 0.88 | HPGD (0.49) | HPGDEPHX1RECQLKDM4EMAPT | |
| SCHEMBL118661 | 0.88 | HPGD (0.48) | HPGDEPHX1L3MBTL1RECQLKDM4E | |
| SCHEMBL994288 | 0.88 | HPGD (0.58) | HPGDEPHX1L3MBTL3RECQLKDM4E | |
| SCHEMBL31583968 | 0.86 | HPGD (0.47) | HPGDEPHX1RECQLKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976842-A1 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | Siena Biotech S.p.A. (IT) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007082731-A1 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | SIENA BIOTECH S.P.A. (IT) | 2007-07-26 | — | — | WO | disclosed |