Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.74 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.46 |
| ▸ | NPR1 | P16066 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608756 | 1.00 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11NPR1 | |
| SCHEMBL4609534 | 0.92 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4609540 | 0.92 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4608596 | 0.91 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4625103 | 0.91 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4609169 | 0.91 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4609172 | 0.91 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4608719 | 0.90 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4626110 | 0.90 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4836783 | 0.89 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747204-B1 | TRI-SUBSTITUTED UREAS AS CYTOKINE INHIBITORS | PROCTER & GAMBLE (US) | 2008-07-30 | — | — | EP | claimed |