Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 6/20 | 0.69 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.69 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.69 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.69 |
| ▸ | CPS1 | P31327 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4626688 | 1.00 | PDK2 (0.69) | PDK2PDK1PDK3PDK4CPS1 | |
| SCHEMBL4627915 | 0.86 | PDK2 (0.74) | PDK2PDK1PDK3PDK4 | |
| SCHEMBL4627918 | 0.86 | PDK2 (0.74) | PDK2PDK1PDK3PDK4 | |
| SCHEMBL4627214 | 0.85 | PDK2 (0.72) | PDK2PDK1PDK3PDK4 | |
| SCHEMBL4627212 | 0.85 | PDK2 (0.72) | PDK2PDK1PDK3PDK4 | |
| SCHEMBL4627646 | 0.84 | PDK2 (0.71) | PDK2PDK1PDK3PDK4 | |
| SCHEMBL4627641 | 0.84 | PDK2 (0.71) | PDK2PDK1PDK3PDK4 | |
| SCHEMBL4626163 | 0.83 | PDK2 (0.69) | PDK2PDK1PDK3PDK4 | |
| SCHEMBL4626158 | 0.83 | PDK2 (0.69) | PDK2PDK1PDK3PDK4 | |
| SCHEMBL3890041 | 0.83 | DRD3 (0.63) | CPS1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214287-B1 | AMIDES AS INHIBITORS FOR PYRUVATE DEHYDROGENASE | ASTRAZENECA AB (SE) | 2008-07-02 | — | — | EP | disclosed |