Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 13/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 10/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 9/20 | 0.37 |
| ▸ | RET | P07949 | 6/20 | 0.37 |
| ▸ | JAK2 | O60674 | 6/20 | 0.37 |
| ▸ | KDR | P35968 | 5/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.37 |
| ▸ | INSR | P06213 | 3/20 | 0.37 |
| ▸ | LYN | P07948 | 3/20 | 0.37 |
| ▸ | MET | P08581 | 3/20 | 0.37 |
| ▸ | ROS1 | P08922 | 3/20 | 0.37 |
| ▸ | FGR | P09769 | 3/20 | 0.37 |
| ▸ | KIT | P10721 | 3/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.37 |
| ▸ | TIE1 | P35590 | 3/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL447003 | 0.81 | NTRK1 (0.48) | NTRK1NTRK2NTRK3RETJAK2 | |
| SCHEMBL431997 | 0.81 | NTRK1 (0.48) | NTRK1NTRK2NTRK3RETJAK2 | |
| SCHEMBL446595 | 0.76 | NTRK1 (0.43) | NTRK1NTRK2NTRK3RETJAK2 | |
| SCHEMBL30875980 | 0.76 | NTRK1 (0.61) | NTRK1NTRK2NTRK3RETJAK2 | |
| Hydrochloric Acid SCHEMBL31748851 | 0.75 | NTRK1 (0.60) | NTRK1NTRK2NTRK3RETJAK2 | |
| SCHEMBL464590 | 0.72 | NTRK1 (0.40) | NTRK1NTRK2NTRK3RETJAK2 | |
| SCHEMBL30458927 | 0.66 | NTRK1 (0.59) | NTRK1NTRK2NTRK3RETJAK2 | |
| SCHEMBL23535604 | 0.64 | CLK4 (0.63) | NTRK1NTRK3RETJAK2KDR | |
| SCHEMBL430860 | 0.62 | NTRK1 (0.44) | NTRK1NTRK2NTRK3RETJAK2 | |
| SCHEMBL464583 | 0.62 | NTRK1 (0.44) | NTRK1NTRK2NTRK3RETJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614062-A1 | IMIDAZO [1, 2]PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012034091-A1 | IMIDAZO [1, 2] PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | disclosed |